The AutoDBS-1 is the first in a line of low cost DBS bio-sampling instrument, designed to simplify the extraction of blood components from a Tomtec or third-party DMPK Card via a 3 or 5 mm punch. This semi-manually operated instrument interfaces with LIMS to track the extracted plugs as they are transferred to 96 well assays. Sample tracking is maintained via the barcode on each Tomtec DMPK card. To extract a plug, a user places the Tomtec DBS card on an indexing tray. The designated target (blood spot to be punched), is back lit to identify it. The user then positions the targeted spot under a set of illuminated cross-hairs and the plug is automatically extracted.